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Goal: <140/90
< 130/80 if diabetic or renal disease
Therapy:
120-139 or 80-89 |
140-159 or 90-99 |
>160 or >100 |
Lifestyle Modifications (mengubah gaya hidup, nek kowe do rangerti bahasane) |
Thiazide-type diuretics yang utama. boleh dipertimbangkan ACEI, ARB, BB, CCB, or combination. |
dua obat kombinasi dari yang palign sering digunakan biasanya thiazidetype diuretic and ACEI, or ARB, or BB, or CCB). |
keterangan obat :
Thiazide –type =chlorothiazide
ACEI =angiotensin-converting enzyme inhibitors=LISINOPRIL and CAPTOPRIL
ARB =Angiotensin Receptor Blocker=Losartan, irbesartan, olmesartan, candesartan, and telmisartan
BB=beta blocker=propanolol, atenolol
CCP =calcium channel blocker,
ALDO ANT=aldosterone antagonist
Compelling indications:
• Heart failure: THIAZ, BB, ACEI, ARB, ALDO ANT
• Post myocardial infarction: BB, ACEI, ALDO ANT
• High CVD risk: THIAZ, BB, ACEI, CCB
• Diabetes: THIAZ, BB, ACEI, ARB, CCB
• Chronic kidney disease: ACEI, ARB (Obat ini bersifat renoprotektif/nefroprotektif sehingga cocok untuk penderita yang ginjalnya rusak seperti komplikasi DM—hal ini dikarenakan ACEI atau ARB menyebabkan vasodilatasi pada ginjal)
• Recurrent stroke prevention: THIAZ, ACEI
Identifiable causes of HTN:
• Sleep apnea |
• Cushing’s syndrome |
• Drug induced/related |
• Steroid therapy |
• Chronic kidney disease |
• Pheochromocytoma |
• Primary aldosteronism |
• Coarctation of aorta |
• Renovascular disease |
• Thyroid/parathyroid disease |
CVD Risk factors:
• Hypertension |
• Physical inactivity |
• Obesity (body mass index >30 kg/m2) |
• Age (>55 for men, >65 for women) |
• Dyslipidemia |
• Diabetes mellitus |
• Microalbuminuria, est GFR <60 mL/min |
• FH of early CVD (men age <55, women age <65) |
• Cigarette smoking |
• Physical inactivity |
Lifestyle Modifications:
Weight reduction |
Maintain normal body weight (body mass index 18.5–24.9 kg/m2). |
5–20 mmHg/10 kg |
DASH eating plan |
Adopt a diet rich in fruits, vegetables, and lowfat dairy products with reduced content of saturated and total fat. intinya nek kowe duwe penyakit iki, kudu diet Magnesium, Kalsium, dan kalium. Nah…iki kadar tingginya ada di buah – buahan. Trus dihindari konsumsi Na berlebih koyo nang makanan kaleng, makanan instan berpengawet ada Na benzoat, dan MSG. |
8–14 mmHg |
Dietary sodium reduction |
Reduce dietary sodium intake to <100 mmol per day (2.4 g sodium or 6 g sodium chloride). |
2–8 mmHg |
Aerobic physical activity |
Regular aerobic physical activity (e.g., brisk walking) at least 30 minutes per day, most days of the week. |
4–9 mmHg |
Moderation of alcohol consumption |
Men: limit to <2 drinks per day. Women and lighter weight persons: limit to <1 drink per day. |
2–4 mmHg |
Contraindications and Side Effects:
THIAZ |
gout, HypoNa, hypoK |
BB |
Asthma, heart block, cocaine use, bradycardia |
ACEI |
Pregnancy, angioedema, cough |
CCB |
Edema, flushing |
ARB |
Pregnancy, angioedema |
2ndary benefits:
angina: nitrates
BPH: a-blocker
Migraine: b-blocker, calcium channel blocker
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